Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GNAI1 contributors: mct/npt - updated : 11-04-2015
HGNC name guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
HGNC id 4384
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three regions named switches 1, 2 and 3 and including the sites for guanine nucleotide binding and effector interaction
  • an helical domain
  • HOMOLOGY
    Homologene
    FAMILY
  • G protein family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • guanine nucleotide-binding protein having alpha inhibiting activity
  • are involved as modulators or transducers in various
  • transmembrane signaling systems
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • guanine nucleotide binding
  • interaction with RGS14 (selective interactions between GNAI1, GNAI3 and the GoLoco domain of RGS14 influence its dynamic subcellular localization) (
  • links GNAI1 proteins to inhibit GNAQ-induced RAS/ERK1/2 activation
  • is a GTPase-activating protein for the GNAQ and GNAI1 subunits of heterotrimeric G-proteins that turns off signaling by G-protein coupled receptors
  • GAP43 is involved in the orientation of cell division by interacting with GNAI1 and this should be an important mechanism for neurogenesis in the mammalian brain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    being a critical factor leading to cellular electrophysiological remodeling and cardiac arrhythmias in hypertrophic cardiomyopathy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS