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FLASH GENE
Symbol NAT2 contributors: npt/ - updated : 13-10-2007
HGNC name N-acetyltransferase 2 (arylamine N-acetyltransferase)
HGNC id 7646
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Nat2
homolog to rattus nat1
Homologene
FAMILY
  • arylamine N-acetyltransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • arylamine N-acetyltransferase 2, polymorphic
  • responsible for slow or rapid acetylation of arylamine and hydrazine drugs and able to bioactivate several known carcinogens
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NAT2D
    related resource Arylamine N-Acetyltransferase (Note- Not really a variation database but useful-lists alleles & nomenclature)
    Susceptibility
  • susceptibility gene for bladder cancer
  • putative susceptibility factor in squamous-cell carcinoma of the esophagus and colorectal cancer and in systemic lupus erythematosus
  • putative susceptibility factor for idiopathic talipes equinovarus (clubfoot)
  • sucseptibility to age-related hearing impairment
  • to drug-induced hepatotoxicity in tuberculosis and rheumatoid arthritis patients
  • Variant & Polymorphism other
  • in slow activator male patients, particularly when the genotype NAT2*5B/6A was combined with the GTSM1 null phenotype and breast cancer and the genotype NAT2*7 is an important factor in tumorigenesis of colorectal cancer
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS