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FLASH GENE
Symbol ANXA7 contributors: mct - updated : 19-10-2007
HGNC name annexin A7
HGNC id 545
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • a long hydrophobic 167 AA N terminus
  • a C terminal "core" region
  • four repeats homolog to the endonexin fold
  • HOMOLOGY
    interspecies homolog to murine Anxa7
    homolog to C.elegans T07C4.9
    Homologene
    FAMILY
  • annexin family of calcium-dependent phospholipid binding protein
  • CATEGORY tumor suppressor , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic
    text stomatin, sorcin, and synexin were shown to locate mainly outside induced GM1 (ganglioside M1) patches in the human erythrocyte membrane
    basic FUNCTION
  • promoting membrane fusion
  • membrane binding protein with voltage-sensitive calcium channel activity, ion selectivity and membrane fusion
  • mediating galectin-3 (LGALS3) translocation to the perinuclear mitochondrial membranes, where it regulates mitochondrial integrity critical for apoptosis regulation
  • ANXA7 and sorcin are cytosolic proteins that are actors in vesicular trafficking and exocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport
    text voltage dependent calcium channel
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • calcium Ca2+
  • phospholipid
  • protein interacting with LGALS3
    cell & other membrane
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in prostate cancer especially metastatic
    tumoral   LOH    
    in hormone receptor negative breast carcinomas with poor prognosis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    Anxa 7 -/- mice (Herr, 2001)