SUBCELLULAR LOCALIZATION
| intracellular
|
| intracellular,cytoplasm,cytosolic
|
| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
|
| intracellular,nucleus
|
| intracellular,nuclear envelope,pore
|
text
| cytoplasmic face of nucleopore |
|
localizes to the cytoplasmic side of the nuclear pore complex as part of the cytoplasmic filaments (Napetschnig 2009) |
|
exogenously expressed full-length NUP214 was localized predominantly at the nuclear envelope, suggesting its integration in the nuclear pore complex (NPC) |
|
localized on the spindles together with NUP214 during mitosis (Hashizume 2010) |
|
found at the cytoplasmic side of the nuclear pore complex (NPC) |
basic FUNCTION
| may serve as a docking site in the receptor mediated import of substrates across the nuclear pore complex (NPC) |
|
specific role of NUP214 in protein export is furthered by the biochemical properties of a high-affinity complex containing NUP214, CRM1, RanGTP, and an export cargo |
|
NUP214 interacts with VDR and modulates its function as a transcription factor |
|
DEK-NUP214 fusion protein appears defective, at least in part, in assisting transcriptional regulation of certain genes that might be essential for normal differentiation of hematopoietic cells (Sawatsubashi 2010) |
|
implicated in nuclear protein export rather than import |
|
NUP62 and nucleoporin 214 (NUP214) are differentially distributed between nuclear pore complexes on the flattened surfaces and peripheral rim of the nucleus |