basic FUNCTION
| involved in classical pathway of C3 |
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acting as a chemoattractant for neutrophils |
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induces maturation of human dendritic cells |
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cooperative interaction between C1QA and PRNP could represent an early step in the disease, where it prevents elimination of the prion seed, leading to further aggregation |
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dendritic cells pericellular C1QA may induce tolerogenic properties in developing dendritic cells |
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primary component of the classical complement pathway, that is a cone photoreceptor neuronal survival factor |
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important role of complement C1QA in the innate immune response |
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activates canonical Wnt signaling and promotes aging-associated decline in tissue regeneration |
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unexpected role in Wnt signal transduction and modulation of mammalian aging |
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C1QA binds to the nucleolus in advanced apoptotic cells, and the C1QA-associated C1R/C1S proteases degrade nucleolar proteins |