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FLASH GENE
Symbol MSMB contributors: mct/npt/pgu - updated : 15-02-2018
HGNC name microseminoprotein, beta-
HGNC id 7372
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • beta-microseminoprotein family
  • immunoglobulin superfamily
  • CATEGORY regulatory , secretory
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,nucleus
    basic FUNCTION
  • may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues
  • playing a role in hormonal control at the pituitary gonadal axis
  • functions as a suppressor of tumor growth and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component seminal plasma protein, forming a tight complex with cysteine-rich secretory protein 3 (CRISP3) from granulocytes
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with EZH2 (MSMB is silenced by EZH2 in advanced prostate cancer cells)
  • interact with cysteine-rich secretory protein 3 (CRISP3) in seminal plasma
  • both MSMB and an adjacent gene, NCOA4, are subjected to transcriptional control via androgen response elements
  • MSMB bind human CRISP3 (cysteine-rich secretory protein 3) with very high affinity
  • MSMB is a key upstream factor in mediating PRSS8 signaling that regulates PRSS8 expression and action in ovarian cancer cells
  • CRISP2 is a potential binding protein of MSMB
  • CRISP3 binds specifically and with high affinity to MSMB
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    suppression of MSMB expression promotes anchorage-independent growth of prostate epithelial cells, but not growth of breast epithelial cells
    tumoral     --low  
    in ovarian cancer with reduced survival
    Susceptibility
  • to prostate cancer, HPC13 (OMIM 611928)
  • to spermatogenic failure associated with male infertility
  • Variant & Polymorphism SNP
  • increasing the risk of prostate cancer
  • rs10993994 is the strongest associated variant to risk of prostate cancer
  • rs10993994 associated with risk of spermatogenic failure
  • Candidate gene
    Marker
  • prostate cancer (PC) biomarker
  • Therapy target
    ANIMAL & CELL MODELS