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FLASH GENE
Symbol PVT1 contributors: mct/npt/pgu - updated : 31-08-2016
HGNC name Pvt1 oncogene homolog (mouse)
HGNC id 9709
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to plasmocytoma variant translocation (pvt-1) murine oncogene
Homologene
FAMILY
CATEGORY protooncogene
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • preferential integration site of MuLV in mouse
  • c-myc activator (260kb, 3')
  • playing a role in mediating susceptibility to end-stage renal disease attributable to diabetes
  • essential for the maintenance of cell size of cardiomyocytes and might play a role in the regulation of cardiac hypertrophy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • downstream target of Myc proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PVT1
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification    
    in breast and ovarian cancer associated with reduced survival duration in patients treated with agents that act through apoptotic mechanisms
    tumoral fusion      
    PVT1-MYC fusion in Group 3 medulloblastoma
    tumoral     --over  
    in gastric carcinoma promotes the development of multidrug resistance (MDR), suggesting an efficacious target for reversing MDR in gastric cancer therapy
    Susceptibility
  • to end-stage renal disease (ESRD) in type 1 diabetes
  • to Hodgkin lymphoma
  • Variant & Polymorphism SNP , other
  • a common haplotype containing the C allele at rs10808565 and the A allele at rs13447075 that was associated with ESRD
  • association between SNP rs2720709 and ESRD (Hanson 2007)
  • SNP increasing the risk of Hodgkin lymphoma
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS