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FLASH GENE
Symbol ORM1 contributors: npt/ - updated : 18/12/2008
HGNC name orosomucoid 1
HGNC id 8498
PROTEIN
PHYSICAL PROPERTIES other
STRUCTURE
motifs/domains
secondary structure a single eight-stranded continuously hydrogen-bounded antiparallel beta-barrel which encloses an internal ligand binding site
conjugated GlycoP , Other
mono polymer monomer
HOMOLOGY
interspecies homolog to rattus Orm1 (52.6 pc)
homolog to murine Orm1 (50.3 pc)
Homologene
FAMILY
  • calycin superfamily
  • lipocalin family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing a crucial role in maintaining homeostasis
  • modulating the activity of the immune system during the acute-phase reaction
  • may be involved in aspects of immunosuppression
  • affecting pharmacokinetical properties of various therapeutic agents
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense , inflammation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by glucocorticoids, interleukin-1 and interleukin-6 (increased 5- to 50-fold upon inflammation)
    Other pyrrolidone carboxylic acid
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS