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FLASH GENE
Symbol IARS contributors: mct - updated : 16-09-2016
HGNC name isoleucine-tRNA synthetase
HGNC id 5330
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to C.elegans rha8.6
Homologene
FAMILY class 1 aminoacyl tRNA synthetase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • playing a central role in linking amino acids with nucleotide triplets contained in tRNAS
  • IARS enzyme activity seems to be independent of zinc levels and the beneficial effect of zinc supplementation is likely compensating secondary zinc deficiency
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GRIDHH
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS