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FLASH GENE
Symbol CPB1 contributors: mct - updated : 19-03-2008
HGNC name carboxypeptidase B1 (tissue)
HGNC id 2299
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 15AA signal/leader peptide
  • a 94-96-amino acid-long propeptide
  • a catalytic moiety with a zinc binding domain
  • conjugated MetalloP
    isoforms Precursor
    HOMOLOGY
    interspecies homolog to C.elegans y59c2a.1
    Homologene
    FAMILY zinc carboxypeptidase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • modulate the plasminogen system both in the matrix and on the cell surface, thus leading to the inhibition of endothelial cell movement and tube formation
  • cleave off basic C-terminal residues and secreted as inactive zymogens
  • CPB1 hydrolyzes C-terminal lysine and arginine residues generated by tryptic cleavages
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    activated by proteolytic cleavage at the C-terminal end of the propeptide by trypsin
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene serum marker for acute pancreatitis
    Marker
    Therapy target
    ANIMAL & CELL MODELS