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FLASH GENE
Symbol DEFA3 contributors: mct - updated : 21-01-2015
HGNC name defensin, alpha 3, neutrophil-specific
HGNC id 2762
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
cysteine-arginine rich antimicrobial peptide with six disulfide-linked cysteines
HOMOLOGY
Homologene
FAMILY corticostatin/defensin family
CATEGORY immunity/defense
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic,vesicle
text azurophil granules
basic FUNCTION
  • neutrophil antibacterial peptide, involved in oxygen independent phagocytosis of Gram+, Gram- bacteria, many fungi, some viruses
  • contributing to the anti HIV1 activity of CD8 antiviral factor
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    might protect pleomorphic adenomas from malignant transformation into adenocarcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS