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FLASH GENE
Symbol SLA contributors: mct - updated : 29-11-2011
HGNC name Src-like-adaptor
HGNC id 10902
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • domains homolog to SH2 motif and a proline rich region (SH3 binding domain), lacking a tyrosine catalytic domain
  • unique C terminal region
  • HOMOLOGY
    interspecies homolog to murine Src-like adaptor protein (Slap)
    ortholog to murine Mslap
    Homologene
    FAMILY SRC family of cytoplasmic tyrosine kinase
    CATEGORY adaptor , regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • negative regulator of T-cell receptor signaling
  • functions in a pathway that requires the phosphorylated CD247 and the Src family kinase LCK, but not ZAP70 (zeta-associated protein of 70 kD)
  • SLA and CBL recently have been shown to cooperate in regulating T cell receptor (TCR) levels in developing T cells
  • has a conserved function in B and T cells by adapting CBL to the antigen-receptor complex and targeting it for degradation
  • inhibitor of T- and B-cell receptor signaling
  • negatively regulates differentiation of osteoclasts and proliferation of their precursors
  • SLA and SLA2-mediated CSF2RA regulation is important for the generation of functionally mature monocytic dendritic cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    Eck receptor tyrosine kinase signaling pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding the Eck receptor protein tyrosine kinase
  • glucocorticoid-regulated gene but although SLA is a prominent GC response gene, it does not seem to contribute to the anti-leukemic effects of GC
  • cell & other
    REGULATION
    Other transcriptionally regulated by retinoic acid and by activation of B cells
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS