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FLASH GENE
Symbol GSPT1 contributors: mct - updated : 24-11-2015
HGNC name G1 to S phase transition 1
HGNC id 4621
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal unstructured domain (N-domain) and translation elongation factor EEF1A-like GTP-binding domain (C-domain)
  • a leptomycin-sensitive nuclear export signal (NES)
  • a region containing two overlapping PAM2 (PABPC1-interacting motif 2) motifs assumed to bind to the PABC domain of PABPC1
  • HOMOLOGY
    interspecies homolog to yeast cell cycle,G1 to S phase transition 1
    intraspecies homolog to polypeptide chain elongation factor-1 alpha (EF1 alpha)
    Homologene
    FAMILY GTP-binding elongation factor family, ERF3 subfamily
    CATEGORY regulatory , signaling cytokine
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    text
  • is a nucleo-cutoplasmic shuttling protein
  • basic FUNCTION
  • involved in regulation of mammalian cell growth
  • mediating translation termination, and controling the formation of the termination complex by modulating ETF1 protein stability
  • GSPT1 is the major factor acting in translation termination in mammals and GSPT2 can substitute for GSPT1 in this function
  • is a GTPase associated with ETF1 in a complex that mediates translation termination in eukaryotes
  • eukaryotic translation termination is mediated by two interacting release factors, ETF1 and GSPT1, which act cooperatively to ensure efficient stop codon recognition and fast polypeptide release
  • ETF1 recognizes the stop codon in the A site of the ribosome and promotes nascent peptide chain release, and the GTPase GSPT1 facilitates this peptide release via its interaction with ETF1
  • plays pivotal roles in translation termination and post-termination events including ribosome recycling and mRNA decay
  • could serve as a target in the regulation of gene expression
  • functional interplay between two release factors, ETF1 and GSPT1, involved in eukaryotic translation termination, and GTP hydrolysis by GSTP1 couples codon recognition with peptidyl-tRNA hydrolysis by ETF1
  • is a multifunctional protein that plays pivotal roles in translation termination as well as the initiation of mRNA decay, and also functions in the regulation of apoptosis
  • is a novel regulator of cell death
  • CELLULAR PROCESS nucleotide, transcription, elongation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with and stimulating ETF1
  • expression level of GSPT1 controls the formation of the termination complex by modulating ETF1 protein stability
  • proteasomal degradation of GSTP1 controls translation termination complex formation by adjusting the GSPT1 level to that of ETF1
  • important role for ETF1 stimulatory effect on GSPT1 GTPase activity
  • interaction between BIRC5 and GSPT1, GSPT2
  • GSPT1 interact with BIRC5 through the N-terminal domain (NTD: residues 131-200)
  • JMJD4 interacts with the ETF1/GSPT1 translational termination complex in an activity-dependent manner
  • nucleocytoplasmic shuttling protein exported from the nucleus in a manner dependent on CRM1
  • cell & other
    REGULATION
    Other controlled stop-codon directed release
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS