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FLASH GENE
Symbol SPAM1 contributors: mct - updated : 16-09-2014
HGNC name sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
HGNC id 11217
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Spam
homolog to C.elegans y51a2d.13
Homologene
FAMILY family 56 of glycosyl hydrolases
CATEGORY adhesion , enzyme , protooncogene
SUBCELLULAR LOCALIZATION     plasma membrane
text attached to the membrane by a GPI-anchor
basic FUNCTION
  • sperm adhesion molecule possessing hyaluronidase activity
  • involved in sperm-egg interaction
  • is likely to play an important function, possibly in sperm maturation
  • is implicated in fluid reabsorption and urine concentration
  • may function in sperm entry into the cumulus and sperm penetration through the cumulus matrix
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CLU facilitates exchange of glycosyl phosphatidylinositol-linked SPAM1 between reproductive luminal fluids and sperm membranes
  • interaction between SPAM1, ARSA and HSPA2 in a multimeric complex mediating sperm-egg interaction, coupled with the complete failure of this process when HSPA2 is depleted in infertile patients
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in demyelinating lesions and increased SPAM1 expression is sufficient to inhibit Oligodendrocyte progenitor cells (OPCs) maturation and remyelination
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmunemultiple sclerosis
    . Pharmacological inhibition of PH20 may therefore be an effective way to promote remyelination in multiple sclerosis and related conditions
    ANIMAL & CELL MODELS