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FLASH GENE
Symbol CALD1 contributors: mct - updated : 21-08-2014
HGNC name caldesmon 1
HGNC id 1441
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytosolic
intracellular,cytoplasm,cytoskeleton
basic FUNCTION
  • F-actin cross linking protein
  • acts as a potent repressor of cancer cell invasion
  • one of the key regulators for actin dynamics and thereby cell polarity, membrane extension, and cell motility
  • playing a role in the regulation of endothelial cytoskeleton and migration
  • actin- and myosin-binding protein found in smooth muscle that inhibits actin activation of myosin ATPase activity
  • actin-linked regulatory protein found in smooth muscle and non-muscle cells
  • important regulator of axon development
  • CALD1, regulated by SOX4 transcriptional activity, contributes to skeletal muscle differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • biological cascade that involved the phosphorylation activation of CALD1 by CDK14 in promoting formation of actin stress fibers
  • SOX4 is a major trans-acting factor for the regulation of CALD1 expression during myoblast differentiation
  • KAT5 chromodomain was found to facilitate SOX4 recruitment to the CALD1 promoter, which is involved in chromatin remodeling at the promoter
  • cell & other
    REGULATION
    Other its function is regulated qualitatively by Ca2+/CALM1 and by its phosphorylation state and quantitatively at the mRNA level, by three different transcriptional regulation of the CALD1 gene
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS