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FLASH GENE
Symbol ITGB8 contributors: - updated : 26-04-2005
HGNC name integrin, beta 8
HGNC id 6163
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a N terminal signal protein
  • a globular domain
  • a stalk region with four EGF-like repeats each with eight cysteine residues
  • VWFA-like domain
  • a single transmembrane domain (1TM)
  • a cytoplasmic tail
  • conjugated GlycoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Itgb8
    Homologene
    FAMILY integrin beta chain family
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION
    text type I membrane protein
    basic FUNCTION
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component dimerizing with ITGAV in fibronectin, VCAM1 receptors (tail)
    INTERACTION
    DNA
    RNA
    small molecule
    protein ITGAV,VCAM1 receptors
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS