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FLASH GENE
Symbol MEOX2 contributors: mct - updated : 22-01-2011
HGNC name mesenchyme homeobox 2
HGNC id 7014
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • helix-turn-helix, DNA binding domain
  • HOMOLOGY
    interspecies homolog to murine Mox2
    Homologene
    FAMILY
  • homeobox proteins family
  • CATEGORY transcription factor , signaling growth factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • colocalized to the nuclear fraction, with IKBKB and RELA
  • basic FUNCTION
  • important regulator of vertebrate limb myogenesis, and of vascular differentiation
  • involved in regulating epithelial-mesenchymal cell interactions in extraembryonic tissues
  • activates CDKN1A through multiple upstream AT-rich sequences
  • regulate endothelial cell proliferation and muscle development
  • primarily involved in the TGF-beta tumor suppressor pathway
  • with SOSTDC1, may have a role in the progression of Wilms tumorigenesis
  • homeoprotein which inhibits nuclear factor-kappaB (NF-kappaB) signalling and endothelial cells activation in response to serum and proangiogenic factors
  • modulates the activity of the RELA complex through direct interaction with its components
  • an important regulator of vascular cell proliferation and is a direct transcriptional activator of both CDKN1A and CDKN2A
  • MEOX1 and MEOX2 have been shown to be partially functionally redundant during development, suggesting that they regulate similar target genes
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • can form protein complexes with Smads leading to cooperative regulation of CDKN1A gene expression
  • INTERACTION
    DNA binding
    RNA
    small molecule
    protein
  • activating MLLT7
  • interacting with RING finger protein 10 (RNF10)
  • interacts with components of this pathway in vascular ECs (endothelial cells)to modulate NF-kappaB activity and EC activation
  • cell & other
    REGULATION
    activated by MIR221 that upregulates MEOX2 primarily through its ability to downregulate the expression of ZEB2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in Alzheimer disease, by blood vessels dysregulation in the brain
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target therapeutic approach in Alzheimer disease (based on reversing the downregulation of MEOX2)
    SystemTypeDisorderPubmed
    cancerangiogenesis 
    respiratorylung 
    ANIMAL & CELL MODELS