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FLASH GENE
Symbol PTGDS contributors: mct - updated : 17-05-2011
HGNC name prostaglandin D2 synthase 21kDa (brain)
HGNC id 9592
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
interspecies homolog to rattus Ptgds
Homologene
FAMILY
  • calycin superfamily
  • lipocalin family
  • CATEGORY enzyme , transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,nucleus
    basic FUNCTION
  • glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2)
  • involved in the regulation of non-rapid eye movement sleep
  • newly identified melanocyte marker
  • play important roles in both maturation and maintenance of the central nervous system and male reproductive system
  • PTGDS and its receptor chemoattractant receptor homologous molecule expressed on T(h)2 cells (GPR44) have been implicated in the pathogenesis of numerous allergic diseases
  • new regulator of tumor vascular permeability
  • in addition to promoting the recruitment and activation of Th2 cells, may also impede the resolution of allergic inflammation through inhibiting apoptosis of Th2 cells
  • beneficial for protecting the brain against transient and permanent cerebral ischemia
  • catalyses the formation of prostaglandin D(2) (PGD(2)) and also functions as a transporter for lipophilic ligands, including all-trans retinoic acid (RA)
  • lipocalin-type enzyme involved in the metabolism of arachidonic acid and plays a key role in the regulation of sleep, allergy, pain sensation, and the development of male reproductive organs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by IL-1 beta and thyroid hormone
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in cardiac hypertrophy
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    PTGDS agonism may be exploited as a potential therapy for the treatment of cancer
    neurologyneurodegenerative 
    utilized as potential targets to prevent damage following either acute or potentially chronic neurological disorders
    ANIMAL & CELL MODELS