protein
| interacting with Caspase-3 (specifically cleaved PTP-PEST at the (549)DSPD motif and generated fragments, some of which displayed increased catalytic activity) |
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interact with WAS via proline, serine, threonine phosphatase interacting protein (PSTPIP)1 binding |
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tempers T cell activation by dephosphorylating TCR-proximal signaling molecules, such as LCK |
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interaction with PXN (PXN interaction contributes to integrin signaling events associated with the spatiotemporal regulation of key modulators of the cytoskeleton and cell motility machinery) |
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regulatory role of PTPN12 on dephosphorylation of SRC at Y527 and phosphorylation at Y418 in the catalytic site |
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controls PTK2B activity and is a positive regulator of secondary T cell activation |
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suppresses transformation of breast cancer cells by interacting with and inhibiting multiple oncogenic tyrosine kinases, including ERBB2 and EGFR |
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involved with dynamin in dephosphorylation of PTK2B, which is critical for terminating outside-in integrin signaling, and for stabilizing cytoskeletal reorganization during osteoclast bone resorption |
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SKAP2 is a novel substrate of PTPN12 |