Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol HSD17B3 contributors: npt/ - updated : 30-09-2005
HGNC name hydroxysteroid (17-beta) dehydrogenase 3
HGNC id 5212
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Hsd17b3
ortholog to rattus Hsd17b3
Homologene
FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • 17-beta-HSD 3 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • playing an essential role in the formation of active intracellular sex steroids
  • catalyzing the conversion of androstenedione to testosterone (last step of testosterone biosynthesis)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development
    text sex determination
    PATHWAY
    metabolism lipid/lipoprotein , hormone
    signaling
    steroid biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • NADPH
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HSD17B3D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS