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Symbol KLF9 contributors: mct:/SHN - updated : 10-09-2012
HGNC name Kruppel-like factor 9
HGNC id 1123
  • one GC-rich leader sequence in the 5'UTR
  • a highly conserved 81 AA DNA binding domain
  • a DNA binding domain (DBD) consisting of three Cys2-His2 zinc finger domains
    interspecies ortholog to Klf9, Mus musculus
    ortholog to Klf9, Rattus norvegicus
    ortholog to klf9, Danio rerio
    ortholog to KLF9, Pan troglodytes
  • Sp1-like family of GC-box binding transcription factors
  • Krüppel family of transcription factors that bind to GC-rich regions in gene promoters
  • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
  • strongly expressed in nuclei of suprabasal epidermal layers
  • basic FUNCTION
  • GC box binding protein, selectively activating mRNA synthesis from genes containing tandem repeats of GC boxes but repressing genes with a single GC box, like CYP1A1
  • playing a role in the autoinduction of thyroid hormone receptor beta
  • necessary for late-phase maturation of dentate granule neurons both in dentate gyrus development and during adult hippocampal neurogenesis
  • may be involved in the carcinogenesis of human colorectal cancer
  • key pro-adipogenic transcription factor through regulation of PPARG expression with CEBPA at the middle stage of adipogenesis
  • is a transcriptional target of thyroid hormone T3 in some neuronal cell types and is involved in the developmental loss of regenerative ability of retinal ganglion cells
  • circadian transcription factor, that is substantially up-regulated in a cortisol and differentiation-state-dependent manner
  • affects potentially keratinocyte proliferation/differentiation by controlling the expression of target genes in a daytime-dependent manner
  • cell autonomous circadian clock in epidermis with a role of KLF9 for rhythmic modulation of target genes and with implications for dermatological homeostasis and disease
  • functions as clock output gene rather than being part of the core clock machinery
  • reduces the capacity of Purkinje cells (PC) to regenerate their axons
  • the physiological T3 burst in mammals is involved in the developmental loss of PC axon regenerative capacity
  • might be a key molecule involved in turning off the phase of Purkinje programmed cell death (PCD)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    a component
  • interacts with the PPARG promoter (could synergistically activate PPARG promoter by directly interacting with CEBPA)
  • RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • strong activator of AP2alpha
  • progesterone receptor isoforms A and B (
  • KLF9 and GAS2L1 are thyroid hormone receptors target genes
  • acts as a PGR coregulator and, depending on cell context, acts as a negative or positive regulator of ESR1 signaling
  • cortisol dependent KLF9 expression may modulate proliferation of differentiating keratinocytes
  • cell & other
    Other interacting in a mutually exclusive manner within overlapping binding sites within AP2A promoter
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    during the middle stage of 3T3-L1 adipocyte differentiation
    constitutional     --low  
    in colorectal cancer
    Susceptibility to obesity
    Variant & Polymorphism SNP SNP rs11142387 associated with body mass index
    Candidate gene
    Therapy target
  • ablation of the Bteb1 gene in female mice results in uterine hypoplasia, reduced litter size, and increased incidence of neonatal deaths in offspring (
  • mice null for the progesterone receptor (PGR)-interacting protein Krüppel-like factor (KLF) 9 are subfertile and exhibit reduced uterine progesterone sensitivity