Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CACNA2D1 contributors: mct - updated : 18-02-2009
HGNC name calcium channel, voltage-dependent, alpha 2/delta subunit 1
HGNC id 1399
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cache domain
  • a VWFA domain
    • conjugated GlycoP
    mono polymer heteromer , dimer
    isoforms Precursor proteolytically processed into subunits alpha-2-1 and delta-1 that are disulfide-linked
    HOMOLOGY
    interspecies homolog to rattus Cacna2d1 (96.3 pc)
    Homologene
    FAMILY
  • calcium channel subunit alpha-2/delta family
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • single-pass type I membrane protein
  • sarcoplasmic reticulum
  • T-tubule
    • basic FUNCTION
  • regulating calcium current density and activation/inactivation kinetics of the calcium channel
  • playing an important role in excitation-contraction coupling
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text Ca2+ transport
    PATHWAY
    metabolism
    signaling
    a component
  • component of the voltage channel complex
  • dimer formed of alpha-2-1 and delta-1 chains, disulfide-linked
    • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
  • may interact with other cellular components in developing myotubes, such as the ATP5B in its atypical localization in the plasma membrane
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MHS3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS