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FLASH GENE
Symbol RPA3 contributors: mct/pgu - updated : 05-03-2012
HGNC name replication protein A3, 14kDa
HGNC id 10291
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer heteromer , trimer
HOMOLOGY
interspecies homolog to yeast Rfa3
ortholog to Schizosaccharomyces pombe Ssb3
Homologene
FAMILY replication protein A family
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm
basic FUNCTION
  • playing a role in DNA replication, repair, and recombination
  • with RPA1, and RPA2, plays essential roles in DNA transactions
  • single-stranded (ss) DNA-binding protein highly conserved in eukaryotes and playing essential roles in many aspects of nucleic acid metabolism, including replication, recombination, DNA repair and telomere maintenance
  • playing potentially a critical role in mediating RPA functions that are required for repair or tolerance of DNA lesions in S-phase
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, repair, nucleotide excision repair
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • component of a trimeric single strand binding protein,the replication protein A complex,involved in replication,homologous recombination and nucleotide excision repair
  • INTERACTION
    DNA interacting directly with ssDNA
    RNA
    small molecule
    protein
  • interacts with the specific proteins among those that play roles in the regulation of the replication fork progression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS