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FLASH GENE
Symbol ATP6V0A1 contributors: mct/npt/pgu - updated : 06-10-2009
HGNC name ATPase, H+ transporting, lysosomal V0 subunit a1
HGNC id 865
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY
  • V-ATPase 116 kDa subunit family
  • CATEGORY enzyme , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • ATPase H+ transporting, non catalytic accessory protein, vacuolar proton pump 1
  • in the epididymis and vas deferens, the vacuolar H(+)ATPase (V-ATPase), located in the apical pole of narrow and clear cells, is required to establish an acidic luminal pH and also participates in the acidification of intracellular organelles
  • ATP6V0A1, ATP6V0A2 cooperatively regulate the acidification and transmitter uptake/storage of dense-core vesicles, whereas they might not be as critical for exocytosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS active transport
    text hydrogen ion transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • interact with vacuolar type H+-ATPase (ATP6V0A1) which pumps
  • protons at the osteoclast-bone interface
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS