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FLASH GENE
Symbol PMM1 contributors: mct/npt - updated : 26-02-2009
HGNC name phosphomannomutase 1
HGNC id 9114
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to yeast SEC53
intraspecies homolog to PMM2 (66 p100)
Homologene
FAMILY
  • haloacid dehalogenase family of phosphatases / phosphomutases
  • eukaryotic PMM family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the second step in the conversion of fructose-6P to GDP-mannose
  • involved in the glycosylation of glycoconjugates
  • involved in the formation of mannose 1-phosphate needed for glycoprotein biosynthesis (Veiga-da-Cunha 2008)
  • enzyme responsible for Glc-1,6-P2 degradation in ischemic brain (Veiga-da-Cunha 2008)
  • hydrolyse different hexose bisphosphates (glucose 1,6-bisphosphate, mannose 1,6-bisphosphate, fructose 1,6-bisphosphate) (Pirard 1999)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS