basic FUNCTION
| regulating phosphoreceptor membrane guanylyl cyclase RETGC2 in a Ca2+ sensitive manner (but less effective than GCAP1 for stimulating RETGC1) |
|
neuronal calcium sensors, which confer Ca2+ sensitivity to guanylyl cyclase activity |
|
playing a role in regulating the photoresponse |
|
functional EF-hands in neuronal calcium sensor GCAP2 determine its phosphorylation state and subcellular distribution, and are essential for photoreceptor cell integrity |
|
GUCA1A and GUCA1B (or guanylyl cyclase-activating proteins [GCAPs]) have been identified as important mediators of the photoreceptor response to changes in intracellular Ca2+ |