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FLASH GENE
Symbol EYA2 contributors: mct - updated : 21-01-2015
HGNC name eyes absent homolog 2 (Drosophila)
HGNC id 3520
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • C terminal large highly conserved domain,the EYA homology domain,
  • a basic segment followed by an alpha helical domain composed of four successive repeats forming a leucine zipper
  • HOMOLOGY
    Homologene
    FAMILY
  • phosphatase subgroup of the haloacid dehalogenase-like (HAD)hydrolase superfamily
  • CATEGORY unknown/unspecified , receptor membrane tyrosine phosphatase
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • may be involved in eye development
  • participating directly in the modulation of cellular signaling through its phosphatase activity
  • prevents adverse cardiac remodeling under pressure overload partly through altering metabolic gene expression and preserving PI3K/AKT1/MTOR signaling pathway
  • is a necessary co-factor for many of the metastasis promoting functions of SIX1, suggesting that targeting the SIX1-EYA interaction may inhibit breast cancer progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • transcriptional and translational component
  • EYA2-SIX1 complex binds to and enhances the expression of MTOR in a synergistic manner
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SIX1 is dependent on EYA2 to mediate numerous pro-metastatic characteristics
  • EYA2 in a physical complex with SIX1 plays a critical role in physiological hypertrophy of heart
  • FOXG1 binds to mammalian-specific noncoding sequences to repress over 12 transcription factors expressed in early progenitors, including EBF2/3, DMRT3, DMRTA1, and EYA2
  • CDK6 binds to and promotes degradation of the EYA2 protein (interaction suggesting that CDK6 regulates EYA2 activity, a mechanism that could be important in development and in cancer)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    was significantly associated with short overall survival in advanced ovarian cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveovary
    potential application as a therapeutic target in ovarian cancer
    ANIMAL & CELL MODELS