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FLASH GENE
Symbol ACOX2 contributors: mct - updated : 23-05-2012
HGNC name acyl-Coenzyme A oxidase 2, branched chain
HGNC id 120
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a peroxisomal C terminal targeting signal (SKL)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • peroxisomal branched chain trihydroxypristanoyl-CoA oxidase
  • acting on the CoA-esters of bile acid intermediates and pristanic acid
  • key regulatory enzyme of the beta-oxidation pathway 2 for side chain oxidation of cholesterol
  • involved in bile acid production, a process that has been associated with both oxidative stress and regulation of triglyceride levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in preeclampsia (PE), but is a shared risk factor for PE and cardiovascular disease
    Susceptibility to preeclampsia and cardiovascular disease
    Variant & Polymorphism other
  • ACOX2 is a shared genetic risk factor for preeclampsia and cardiovascular disease
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS