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FLASH GENE
Symbol UBE2K contributors: npt - updated : 29-10-2010
HGNC name ubiquitin-conjugating enzyme E2K (UBC1 homolog, yeast)
HGNC id 4914
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a cysteine residue is required for ubiquitin-thiolester formation
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Ubc1
    homolog to C.elegans F40g9.3
    Homologene
    FAMILY
  • ubiquitin-conjugating enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzing the covalent attachment of ubiquitin to other proteins
  • implicated in the degradation of Huntingtin and suppression of apoptosis
  • involved in aggregate formation of expanded polyglutamine proteins and polyglutamine-induced cell death
  • modulates caspase-12 activity via the ubiquitin/proteasome system
  • essential upstream regulator of the expression and activation of caspase-12 in ER stress-mediated Abeta (Amyloid-beta)neurotoxicity
  • mediating the selective degradation of short-lived and abnormal proteins
  • acting as a direct mediator of foam cell formation through polyubiquitination
  • conjugating enzyme that is involved in the cell cycle and suppression of cell death
  • might be involved in the regulation of DIABLO-mediated apoptosis
  • CELLULAR PROCESS cell life, antiapoptosis
    protein, degradation
    protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    text second step in ubiquitin conjugation
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding selctively to a large region at the N terminus of Huntingtin (HD)
  • interacts directly with huntingtin and may mediate ubiquitination of the neuronal intranuclear inclusions in Huntington disease
  • interacting with DIABLO (promoted degradation of mature DIABLO through the ubiquitin proteasome pathway)
  • cell & other
    REGULATION
    induced by low density lipoprotein (LDL)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS