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FLASH GENE
Symbol C6 contributors: - updated : 15-01-2007
HGNC name complement component 6
HGNC id 1339
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • short consensus repeats (Sushi (CCP/SCR) domains)
  • a perforin domain
  • three thrombospondin type I (TSP type-1) domains (see F13B, SRCP1)
  • an EGF-like domain
  • a LDL-receptor class A domain
  • a MACPF domain
  • conjugated GlycoP
    isoforms Precursor
    HOMOLOGY
    interspecies ortholog to murine C6
    ortholog to rattus c6
    ortholog to chimpanzee c6
    Homologene
    FAMILY complement C6/C7/C8/C9 family
    CATEGORY immunity/defense , secretory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • membrane attack complex
  • basic FUNCTION
  • stabilizing C5b
  • involved in the formation of the lytic c5b-9m complex
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • complexing with other late components of the cascade to form the membrane attack complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • C5b
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) C6
    related resource C6base - Mutation registry for C6 deficiency
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS