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FLASH GENE
Symbol ARG1 contributors: shn/npt - updated : 10-05-2009
HGNC name arginase, liver
HGNC id 663
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Two arginine control elements (ARC1 and ARC2)
  • Two Gcn4p binding sites
  • mono polymer homomer , trimer
    HOMOLOGY
    interspecies ortholog to Arg1, Rattus norvegicus
    ortholog to Arg1, Mus musculus
    Homologene
    FAMILY
  • arginase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
  • arginine and proline metabolism
  • urea cycle and metabolism of amino groups
  • metabolism of amino acids
  • a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor,
  • Mn2+
  • protein
  • arginase II (ARG2)
  • nitric oxide synthase 1 (NOS1)
  • the co-activator complex SWI/SNF
  • cell & other
    REGULATION
    activated by Gcn4p
    induced by arginine
    homoarginine
    repressed by Mcm1p
    ASSOCIATED DISORDERS
    corresponding disease(s) ARG1
    Susceptibility to myocardial infarction and common carotid intima media thickness.
    Variant & Polymorphism other Polymorphisms increasing the risk of myocardial infarction and common carotid intima media thickness.
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • knockout mice exhibited severe hyperammonemia and died between postnatal days 10 and 14
  • livers of Arg1-deficient animals showed hepatocyte abnormalities, including cell swelling and inclusion. The mean arginine level in plasma showed of Arg1-knockout mice was 4-fold and 3-fold greater than in wildtype and heterozygous mice, respectively and proline and ornithine levels were reduced
  • Arg1-KO mice duplicate several pathobiologic aspects of human argininemia
  • Arg1/Arg2 double-knockout mice exhibited the phenotype of the Arg1 knockout mice, with the additional absence of Arg2 not exacerbating the phenotype. Arginine levels increased roughly 100-fold and ornithine decreased roughly 10-fold compared with wildtype
  • alpha-keto-delta-guanidinovaleric acid, alpha-N-acetylarginine and argininic acid are increased in brain tissue from Arg1 KO and Arg1/Arg2 double-KO mice