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FLASH GENE
Symbol HIVEP2 contributors: mct - updated : 18-09-2017
HGNC name human immunodeficiency virus type I enhancer binding protein 2
HGNC id 4921
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • ZAS1 and ZAS2 domain
  • 12 T/SPXR/K motifs
  • four C2H2-type zinc fingers
  • HOMOLOGY
    interspecies ortholog to murine Hivep2
    homolog to Drosophila shn
    homolog to C.elegans C46C2.1
    intraspecies paralog to HIVEP1,HIVEP3
    Homologene
    FAMILY
  • Schnurri protein family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • may be functioning as a transcriptional repressor
  • playing a crucial role in maintaining cellular homeostasis at least in part by inhibiting NFKB
  • plays a critical role in cell growth, signal transduction and lymphocyte development
  • regulates Th2-dependent airway inflammation and airway hyperresponsiveness
  • unique and redundant functions reside in the Schnurri protein family that are required for proper skeletal patterning and remodeling
  • large zinc-finger containing protein, which plays a critical role in cell growth, signal transduction and lymphocyte development
  • HIVEP2-mediated repression of NF-kappaB is required for cell survival and the successful generation of memory Th1/Th2 cells
  • transcriptional modulator of bone formation and bone resorption
  • acts to dampen death induced by TCR signalling, thereby allowing positive selection to proceed in response to signals of intermediate strength
  • critical regulator of T-cell development that controls the balance between death and differentiation
  • is considered to play an important role in the activation and function of NK cells and the development of T cell lymphoma
  • nuclear factor-kappaB site-binding protein, tightly binds to the enhancers of major histocompatibility complex class I genes and inflammatory cytokines
  • CELLULAR PROCESS cell life
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to 5'-GGGACTTTCC-3' sequence which is found in the enhancer elements of numerous viral promoters such as those of SV40,CMV or HIV1
    RNA
    small molecule
    protein
  • with TRAF2 to repress TNF/NFKB signal pathway
  • interacts with TCF4
  • CLIC4, a multifunctional protein that traffics between the cytoplasm and nucleus, interacts with HIVEP2 (HIVEP2 and CLIC4 are modifiers of TGF-beta signalling through their stabilization of p-Smad2 and 3 in the nucleus)
  • cell & other
    REGULATION
    induced by mitogen and phorbol ester
    ASSOCIATED DISORDERS
    corresponding disease(s) MRD43
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly depressed in the high malignancy gliomas group (WHO grade IV)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Shn2-deficient mice maintain bone mass at the levels comparable to wild-type sham mice even after ovariectomy-induced bone loss and this correlates with the high levels of mineralization activity in bone marrow cells after ovariectomy
  • deletion of Shn2 and Shn3 in mice impairs growth plate maturation during endochondral ossification but simultaneously results in massively elevated trabecular bone formation
  • Hivep2-knockout mice exhibit several working memory deficits, increased anxiety, and hyperactivity