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FLASH GENE
Symbol PSMB8 contributors: mct/pgu - updated : 03-11-2009
HGNC name proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
HGNC id 9545
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Psmb8
homolog to C.elegans pbs-5
Homologene
FAMILY
  • PSM, proteasome family
  • proteasome B-type family
  • peptidase T1B family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in the degradation of cytoplasmic antigens for MHC class I antigen presentation pathways
  • plays critical roles in major histocompatibility complex class I antigen processing
  • playing a unique role in controlling pathogenic immune responses and provide a therapeutic rationale for targeting PSMB8 in autoimmune disorders
  • having a unique role in cytokine production
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS immunity/defense
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling
    involved in an ATP/ubiquitin-dependent non-lysosomal proteolytic pathway
    a component
  • component 20 S (prosome-macropain) of multicatalytic proteinase complex of proteasome
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
    cell & other
    REGULATION
    activated by IRF1 (IRF1 mediates upregulation of PSMB8 by IFN-gamma and concerted expression of immunosubunits of the proteasome)
    induced by gamma interferon
    ASSOCIATED DISORDERS
    corresponding disease(s) JCMP
    Susceptibility to psoriasis arthropathica
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target PR-957, a selective immunoproteasome inhibitor, is a therapeutic modality for autoimmune disorders such as rheumatoid arthritis
    ANIMAL & CELL MODELS