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FLASH GENE
Symbol NQO2 contributors: mct - updated : 07-03-2008
HGNC name NAD(P)H dehydrogenase, quinone 2
HGNC id 7856
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a specific metal binding site, which is not present in NQO1
  • two histidine nitrogens, one cysteine thiol, and a main chain carbonyl group are involved in metal coordination
  • conjugated FlavoP , PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to murine Nqo2
    intraspecies homolog to NQO1
    Homologene
    FAMILY NAD(P)H dehydrogenase (quinone) family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • catalyzes the two-electron reduction of menadione via the oxidation of N-alkylated or N-ribosylated nicotinamides
  • dihydronicotinamide riboside dependent oxidoreductase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in ovarian carcinoma
    Susceptibility to schizophrenia
    Variant & Polymorphism insertion/deletion deletion of the 29 base pair sequence in the promoter may confer susceptibility to a certain form of schizophrenia
    Candidate gene
    Marker
    Therapy target
  • therapeutic target in ovarian carcinoma, because the addition of the nonbiogenic electron donor dihydronicotinamide riboside (NRH) selectively potentiates the bioactivation of the alkylating agent tretazicar
  • potential target of the quinoline antimalarial compounds
  • ANIMAL & CELL MODELS