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FLASH GENE
Symbol TPD52L1 contributors: mct - updated : 16-02-2008
HGNC name tumor protein D52-like 1
HGNC id 12006
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a highly conserved coiled-coil motif that is required for homo- and heteromeric interaction with other TPD52-like proteins
  • a PEST motif
  • potential glycosylation and phosphorylation sites
  • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    intraspecies paralog to TPD52,TPD52L2
    Homologene
    FAMILY TPD52 family
    CATEGORY protooncogene
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in cell proliferation and calcium signaling
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • homodimerizing with TPD52
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis
  • interacting with 14-3-3 proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in childhood leukemia, lymphoid or myeloid
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS