basic FUNCTION
| putatively involved in cellular transduction |
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implicated in clathrin-mediated internalization of LDL-receptor family members |
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can modulate androgen receptor-mediated cell growth in both normal and malignant prostatic epithelial cells (this could evolve into a new therapeutic strategy of prostate cancer) |
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playing a role in ARH fibroblasts (hypercholesterolemia, severe), where it is apparently required to allow normal translation of LDL receptor mRNA |
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implicated in signal transduction pathways and in protein traffic regulation |
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via SRC and focal adhesion signaling, plays a role in endothelial cell function |
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controls migration and capillary-like tube formation by modulating FAK activity via SRC |
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could attenuate Wnt/beta-catenin signaling by stabilizing AXIN1 and preventing its translocation to the membrane |
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stabilizes AXIN1 and attenuates Wnt/beta-catenin signaling by preventing PPP1CC from binding AXIN1 |
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intracellular adaptor protein proposed to function in endocytosis |
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multidomain cargo-specific endocytic adaptor and a mediator of signal transduction, is a potential integrator of trafficking and signaling |
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is pivotal for endothelial cell migration by affecting VEGFA expression |
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tumour suppressor functions of DAB2 involve modulation of canonical Wnt signalling by regulating the endocytic fate of the LRP6 receptor |
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is the key adaptor in the clathrin-associated endocytic complexes to mediate fibrinogen internalization |
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endocytic adaptor protein involved in clathrin-mediated endocytosis and cargo trafficking |
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has a physiological role in the endocytosis of lipoproteins and cholesterol metabolism |
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negatively regulates TGFB1-induced c-Jun N-terminal kinase (JNK) activation, whereas activation of the Smad pathway is unaffected |
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plays a role in modulating TGF-beta signaling to enhance apoptotic clearance of mammary epithelial cells during involution |
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is required for migration and invasion of prostate cancer cells |
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in the absence of LDLRAP1, DAB2 in liver endothelial cells regulates cholesterol synthesis in hepatocytes |