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FLASH GENE
Symbol PRIM2 contributors: SGE/npt - updated : 14-04-2008
HGNC name primase, DNA, polypeptide 2 (58kDa)
HGNC id 9370
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four putative cysteine ligands
  • an iron-sulfur cluster in DNA primase that contributes to enzymatic activity
  • C-terminal 67 amino acid residues of the p180 subunit are essential for SV40 DNA replication as they are required for binding of the p68 subunit and play a role in the interaction with the primase subunits, p48 and p58
  • mono polymer heteromer , dimer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • eukaryotic-type primase large subunit family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the pol alpha (POLA)/primase complex
  • heterodimer of a small subunit and a large subunit
  • heterotetrameric complex essential for simian vacuolating virus 40 (SV40) DNA replication
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with XRCC1 (Lévy 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS