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Symbol ZNF131 contributors: mct/npt - updated : 29-01-2016
HGNC name zinc finger protein 131
HGNC id 12915
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a BTB (POZ) domain
  • five zinc finger C2H2 type krueppel-like domains
  • three basic regions (BR-1, -2 and -3) (BR-1 and BR-2 are functional nuclear localization signals and as such are designated NLS-1 and NLS-2) (Donaldson 2007)
  • C-terminal region of ZNF131 containing the SUMOylation site is necessary for its inhibition of estrogen signaling
  • conjugated MetalloP
    HOMOLOGY
    interspecies homolog to rattus Zfp131 (92.5 pc)
    homolog to murine Zfp131 (94.4 pc)
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional regulation (Tommerup 1995)
  • playing a role during development and organogenesis as well as in the function of the adult central nervous system (Trappe 2002)
  • acting as a repressor of ESR1 signaling (Han 2008)
  • is a transcriptional activator, a less common function of POZ-ZF proteins, that is negatively regulated by its heterodimerization partner ZBTB33
  • inhibits estrogen signaling by acting as an ESR1-co-repressor
  • attenuates estrogen signaling by inhibiting ESR1 homo-dimerization
  • required for Glioblastoma stem-like cell (GSC) viability, but dispensable for neural progenitor cell (NPC) viability
  • ZNF131 suppresses centrosome fragmentation in glioblastoma stem-like cells through regulation of HAUS5
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacted preferentially with the nuclear import receptor Importin-alpha3 (Donaldson 2007)
  • is a ZBTB33-specific binding partner
  • ZNF131, recruits EMSY to a large number of active, H3K4me3 marked promoters
  • UHRF2 effectively enhances zinc finger protein 131 (ZNF131) SUMOylation but does not enhance ZNF131 ubiquitination
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS