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FLASH GENE
Symbol MEP1A contributors: - updated : 27-10-2005
HGNC name meprin A, alpha (PABA peptide hydrolase)
HGNC id 7015
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal peptide,
  • a propeptide,
  • a protease domain containing an astacin signature,
  • a meprin A-5 protein tyrosine phosphatase mu(MAM),
  • a meprin and TRAF homology (MATH)domain,
  • an after MATH (AM) domain,
  • an EGF like domain,
  • a putative transmembrane segment (1TM)
  • a short cytoplasmic tail
  • conjugated GlycoP
    mono polymer homomer , heteromer , oligo
    HOMOLOGY
    Homologene
    FAMILY astacin family of zinc metalloendopeptidases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text secreted forms
    basic FUNCTION hydrolysing basement membrane components such as collagen IV, nidogen-1 and fibronectin
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component associating with MEP1B
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS