Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol OXCT1 contributors: mlc - updated : 24-03-2006
HGNC name 3-oxoacid CoA transferase 1
HGNC id 8527
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a transit peptide
  • a CoA binding site
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies ortholog to murine Oxct1
    homolog to chicken OXCT1
    Homologene
    FAMILY 3-oxoacid CoA-transferase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,matrix
    basic FUNCTION
  • catalyzes the reversible transfer of CoA from succinyl-CoA to acetoacetate
  • rate determining step of ketolysis in extrahepatic tissues, acetoacetate esterification for use in energy production
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism energetic
    signaling
    succinylcoA metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by thyroid hormones
    ASSOCIATED DISORDERS
    corresponding disease(s) OXCT
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS