Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CYB5A contributors: npt/ - updated : 03-04-2007
HGNC name cytochrome b5 type A (microsomal)
HGNC id 2570
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • cytochrome b5 heme-binding domain
  • a blocked N terminus
  • conjugated HemoP
    HOMOLOGY
    interspecies ortholog to murine Cyb5
    ortholog to rattus cyb5
    Homologene
    FAMILY
  • cytochrome b5 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • cofactor of diaphorase (DIA1), enhancing its ability to catalyze the transfer of electrons from NADH to methemoglobin
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS electron transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • iron Fe2+, Fe3+
  • protein
  • interacting with cytochrome P450 2E1
  • enhancing 17,20 lyase activity independently of each other, probably by increasing the interaction between P450c17 and NADPH-cytochrome P450 oxidoreductase
  • interacting with visinin-like protein-3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CYB5D
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS