SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,nucleolus
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| localizes mainly in the nucleolus, where it forms a complex with different cellular proteins |
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citrullination of NPM1 by PADI4 resulted in its translocation from the nucleoli to the nucleoplasm |
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mainly localizes in nucleole, but it shuttles between the nucleolus/nucleoplasm and nucleus/cytoplasm ( |
basic FUNCTION
| nucleus-cytoplasmic shuttling protein that is implicated in centrosome duplication, cell cycle progression and stress response |
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target of CDK2/cyclin E in the initiation of centrosome duplication |
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promoting the biogenesis of the ribosome by acting as a chaperone that carries preribosomal particles from the nucleolus to the cytoplasm |
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modulating the function of tumor suppressor transcription factors such as IRF1 and TP53 |
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being essential for embryonic development and the maintenance of genomic stability |
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multifunctional protein, involving in a wide variety of basic cellular processes, including ribosome assembly, DNA duplication, nucleocytoplasmic trafficking, and centrosome duplication |
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may be playing a role in the centriole pairing |
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being critically involved in 28S rRNA maturation after deconjugation of SUMO2 by SENP3 |
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abundant shuttling phosphoprotein, which plays important roles in ribosome biogenesis and which has been strongly implicated in hematopoietic malignancies |
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may be involved in regulation of SUMO deconjugation |
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acetylated protein localized to the nucleoplasm and regulates transcriptional activation of genes involved in oral cancer manifestation |
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may act as an oncogene or an oncosuppressor depending on the cell context |
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exhibited remarkable linker histone HIST1HA1 chaperone activity |
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important member of the linker histone chaperone family |
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may function in the assembly of the kinetochore complex by interacting with CENPW during interphase |
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NPM1 and NPM2 mediated nucleosome assembly independently of other NPM proteins |
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the NPM proteins (NPM1, NPM2, NPM3) cooperatively regulate chromatin disassembly and assembly in the early embryo and in somatic cells |
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is a nuclear protein that regulates a variety of cell functions including centrosomal duplication, cell cycle control, and apoptosis |
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involved in a variety of functions, including the regulation of centrosomal duplication, the cell cycle, mitosis, apoptosis, and RNA and DNA replication, and it also serves as a chaperone for proteins such as histones |
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is a multifunctional protein that participates in cell survival signaling by shuttling between the nucleolus/nucleoplasm and nucleus/cytoplasm |
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regulates neuronal survival by preventing SIAH1–GAPDH death signaling under stress-induced conditions in the brain |
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it is possible that NPM1 regulates ubiquitin dynamics by both deubiquitination and ubiquitination of nuclear proteins to provide rapid neuroprotection |
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novel mechanism that regulates telomerase activation through the interaction between NPM1, PINX1 and the telomerase complex |