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FLASH GENE
Symbol TPM3 contributors: mct/npt - updated : 30-05-2018
HGNC name tropomyosin 3
HGNC id 12012
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer dimer
HOMOLOGY
Homologene
FAMILY
  • tropomyosin family
  • CATEGORY motor/contractile
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microfilament
    basic FUNCTION
  • playing a central role in association with the troponin complex, in the calcium dependent regulation of vertebrate striated
  • having functions in regulating cell motility and in modulating the anti-angiogenic activity of cleaved high molecular weight kininogen (HKa)(Jin 2008)
  • promotes the formation of filopodia by regulating the recruitment of actin-binding proteins to actin filaments
  • its expression has an important role in temporal regulation of cell migration during wound healing
  • plays crucial roles in maintaining cortical actin integrity and asymmetric cell division during oocyte maturation, and dynamic regulation of cortical actin by TPM3 is critical to ensure proper polar body protrusion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text slow type I muscle fibers
    PATHWAY
    metabolism
    signaling
    a component
  • dimerizing to form a helical coiled coil constituent binding to actin in the troponin complex (thin filamant) that regulates calcium-dependent binding of actin and myosin and muscle contraction
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ACTA1 and TNNT1 and ultimatily regulating the development of muscle contraction
  • TTC9 interacts specifically with actin-binding protein tropomyosin TPM3 which stabilizes actin filament and focal adhesion
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEM1 , CFTD3
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    fusion with NTRK1 in papillary thyroid carcinoma, with ALK in anaplastic large cell lymphoma
    tumoral fusion      
    with PDGFRB in chronic eosinophilic leukemia (Rosati 2006)
    tumoral     --over  
    may be important in esophageal squamous cell carcinoma (ESCC) invasion and metastasis (pMID: 28138712)
    constitutional   deletion    
    cause a hypercontractile congenital muscle stiffness phenotype
    tumoral fusion      
    TPM3-ALK fusion gene, is the main causes of Inflammatory myofibroblastic tumor (IMT)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • serum anti-TPM3, anti-TMOD3, anti-STOML2 could be new markers for the early diagnosis of endometriosis
  • Therapy target
    SystemTypeDisorderPubmed
    neuromuscularmyopathycongenital
    administration of troponin activators may constitute a promising therapeutic approach to minimize generalized skeletal muscle weakness in Nemaline myopathy
    ANIMAL & CELL MODELS
    Tm slow (Met 9Arg) mice