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FLASH GENE
Symbol HMGCS1 contributors: mct - updated : 21/11/2008
HGNC name 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
HGNC id 5007
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to dog HMGCS1 (96.4 pc)
homolog to rattus Hmgcs1 (94.8 pc)
Homologene
FAMILY
  • HMG-CoA synthase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • condensing acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase
  • catalyzes the condensation of acetyl-CoA and acetoacetyl-CoA into 3-hydroxy-3-methylglutaryl CoA
  • participates in the mevalonate pathway but its end product is cholesterol
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
  • cholesterol biosynthetic process
  • isoprenoid biosynthetic process
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS