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FLASH GENE
Symbol HLA-DPA1 contributors: npt/ - updated : 19-05-2006
HGNC name major histocompatibility complex, class II, DP alpha 1
HGNC id 4938
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two extracellular globular domains, alpha 1, alpha 2
  • a transmembrane segment
  • a cytoplasmic tail, non polymorphic
  • HOMOLOGY
    Homologene
    FAMILY
  • HLA-class II family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,lysosome
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • presenting peptides derived from extracellular proteins to T cells, initiating the adaptive immune response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimerizing with HLA-DPB1, forming the peptide groove between alpha 1 and beta 1 domains
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS