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FLASH GENE
Symbol DBI contributors: mct/ - updated : 08-11-2006
HGNC name diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
HGNC id 2690
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • an hydrophobic binding site for acylCoA esters located within the second helical region
  • an ACBP domain
  • conjugated Other
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Dbi
    homolog to Drosophila tbh
    homolog to C.elegans H13N06.6
    Homologene
    FAMILY
  • ACBP family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducing medium-chain acyl-CoA ester synthesis
  • intracellular lipid-binding protein that transports acylCoA esters
  • displacing diazepan from the benzodiazepine (BZD) recognition sites located on the GABA type A receptor (acting as a neuropeptide to modulate the action of the GABA receptor)
  • downregulating the effects of GABA
  • involved in lipid metabolism and regulated by hormones and feeding status via transcription factors such as sterol regulatory element-binding protein 1 and peroxisome proliferator-activated receptor-gamma (PPARgamma)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text intracellular carrier of acyl-CoA esters
    PATHWAY
    metabolism lipid/lipoprotein
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of (PPAR)gamma
  • sterol regulatory element-binding protein 1c (SREBP-1c) target gene in hepatocytes
  • cell & other
  • binding to medium and long-chain acylCoA esters
  • REGULATION
    induced by induced during adipocyte differentiation
    Other regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS