SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endosome
|
| intracellular,cytoplasm,cytosolic,microsome
|
| intracellular,nucleus
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text
| plasma membrane and the microsome fractions of the COS-7 cells |
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constitutively present in the nucleus of cells belonging to distinct lineages and furthermore, nuclear CD38 appears to be independent of the plasma membrane pool |
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expressed in endosomes |
basic FUNCTION
| acting as an ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase |
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leukocyte activation antigen involved in numerous immune functions coreceptor |
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being a coreceptor with MHC class II molecules in superantigens of viral or bacterial origine (SAG) induced proliferation of T cells |
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involved in synthesis and hydrolysis of cADP-ribose in the process of insulin secretion in pancreatic beta-cells |
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involved in the induction of apoptosis by extracellular signals |
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catalyzing the synthesis of the calcium mobilizing molecule cyclic ADP-ribose from NAD |
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play important roles in the physical function and structural stability of the proteins on cell surfaces |
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may play an important role in vivo in regulating humoral immune responses |
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has a key role in neuropeptide release, and in regulating maternal and social behaviours, and may be an element in neurodevelopmental disorders |
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catalyzes the synthesis of second messengers and has been implicated in the regulation of a wide variety of signaling pathways |
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have dual functions not only as a receptor but also as a multifunctional enzyme,catalyzing the synthesis of and hydrolysis of a general calcium messenger molecule, cyclic ADP-ribose(cADPR) |
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undergoes dramatic structural changes to an inhibited conformation in the presence of calcium and structural changes are highly localized and occur in only two regions |
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NAD-utilizing enzyme, is capable of catalyzing the cleavage reactions through both covalent and noncovalent intermediates, depending on the substrate used |
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nuclear CD38 during different stages of hematopoietic differentiation suggests that it may play a role in the control of nuclear Ca(2+) homeostasis and NAD level |
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with BST1, are NAD(+)-consuming ectoenzymes and surface receptors |
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required for endogenous NAADP (Nicotinic acid adenine dinucleotide phosphate) generation in response to CCK stimulation |
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NAADP synthase required for coupling receptor activation to NAADP-mediated Ca2+ release from lysosomal stores in pancreatic acinar cells |
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NAADP degrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells |
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an essential regulator of embryonic development |