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FLASH GENE
Symbol CD8B contributors: npt - updated : 28-03-2012
HGNC name CD8b molecule
HGNC id 1707
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an immunoglobulin-like V-type domain
  • a stalk region having an essential role in ensuring functionality of the CD8alphabeta heterodimer and its replacement compromises the interaction of CD8 with peptide-MHC complexes
  • conjugated GlycoP , PhosphoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Cd8b
    Homologene
    FAMILY
  • immunoglobulin superfamily
  • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • mediating efficient cell-cell interactions within the immune system
  • acting as a coreceptor
  • is crucial in orienting the CD8alphabeta heterodimer, providing a framework for understanding the mechanistic role of CD8alphabeta in lymphoid cell signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text anti-pathogen response
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimer composed of one alpha and one beta chain linked by two disulfide bonds
  • with CD8A, forms CD8alphabeta heterodimer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS