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FLASH GENE
Symbol ADH1B contributors: mct/npt - updated : 30-06-2016
HGNC name alcohol dehydrogenase IB (class I), beta polypeptide
HGNC id 250
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc-binding dehydrogenases
  • conjugated MetalloP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • alcohol dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • alcohol dehydrogenase (class I), beta polypeptide, zinc dependent, plays a major role in ethanol catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    ethanol
    a component
  • homo- and heterodimers of alpha, beta, and gamma subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • putative susceptibility factor for alcoholism
  • to esophageal squamous cell carcinoma (ESCC)
  • to genotoxicity induced by alcohol drinking
  • Variant & Polymorphism SNP , other
  • ADH1B*2 protective against alcoholism in Jewish and in Asian population and susceptibility in caucasians
  • ADHB allele 3 protective among African- Americans
  • SNP rs1229984, alcohol drinking, and smoking are independent risk factors for ESCC (Cui 2009)
  • associations between ADH1B/ALDH2 polymorphisms and genotoxicity in alcohol drinkers (Ishikawa 2007)
  • Candidate gene
    Marker
  • is a favorable prognostic factor for lung adenocarcinoma but an unfavorable prognostic factor for stomach adenocarcinoma
  • Therapy target
    ANIMAL & CELL MODELS