Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AGA contributors: npt/ - updated : 13-10-2006
HGNC name aspartylglucosaminidase
HGNC id 318
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal peptide of 23 AAs is removed in the ER, and then dimerization and glycosylation of the two precursor peptides occur (Saito 2008)
  • conjugated GlycoP
    mono polymer heteromer , tetramer
    isoforms Precursor inactive AGA precursor consisting of 346 amino acid residues on endoplasmic reticulum (ER)-bound ribosomes (Saito 2008)
    HOMOLOGY
    interspecies ortholog to murine Aga
    Homologene
    FAMILY
  • Ntn-hydrolase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • involved in the catabolism of N-linked oligosaccharides of glycoproteins
  • cleaving asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , other
    signaling
    catabolism of glycoproteins (protein deglycosylation)
    a component
  • heterotetramer of two alpha and two beta chains bound by disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other targeted to the lysosome by M6P receptor mediated pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) AGU
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS